Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Adenophora, particularly Adenophora stricta and Adenophora triphylla, has a long history of use in traditional East Asian medicine, including Traditional Chinese Medicine (TCM) and Korean herbal medicine. It is often known as "Sha Shen" in TCM and is used to "moisten the lungs," "clear heat," and "relieve sore throat" or dryness. The root is the part most commonly used, and it is typically included in herbal formulas aimed at treating respiratory discomforts such as dry cough, hoarseness, and sore throat.

There is limited scientific evidence to directly support its efficacy in treating sore throat. Some pharmacological studies have identified that extracts of Adenophora show anti-inflammatory and immunomodulatory activities in vitro and in animal models, which might theoretically contribute to symptom relief for sore throat. However, controlled clinical trials in humans for sore throat are lacking as of 2024. Most references in the scientific literature point to its ethnomedicinal use rather than robust clinical evaluation.

In summary, the use of Adenophora for sore throat is primarily supported by traditional usage rather than high-quality scientific validation. Its traditional reputation, safety profile in historical use, and some preliminary pharmacological data contribute to a moderate evidence rating, though direct clinical evidence remains insufficient.

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