Evidence supporting the use of: Vitamin B6
For the health condition: Sore or Geographic Tongue

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Vitamin B6 (pyridoxine) has been traditionally used as part of the broader B-complex vitamins for supporting oral mucosal health, including conditions like sore tongue (glossitis) or geographic tongue (benign migratory glossitis). The rationale for using vitamin B6 stems from early 20th-century observations that deficiencies in several B vitamins, particularly B2 (riboflavin), B3 (niacin), B6 (pyridoxine), B9 (folate), and B12, could lead to various oral manifestations such as glossitis, stomatitis, and cheilosis. However, while vitamin B12 and folate deficiencies are more strongly and consistently associated with glossitis and geographic tongue, the direct evidence for vitamin B6’s role is less robust. There are a few case reports and small observational studies suggesting that B6 deficiency can contribute to nonspecific oral discomfort, but high-quality trials or systematic reviews validating B6 supplementation as an effective treatment for sore or geographic tongue are lacking. Most modern guidelines recommend assessing for and correcting any B vitamin deficiency in patients with unexplained tongue pain, but B6 is not singled out as a primary intervention. Thus, while the traditional use of B6 for tongue issues persists in some circles, scientific evidence supporting its targeted efficacy for sore or geographic tongue is weak, and empirical supplementation is mainly justified in the context of a documented deficiency rather than as a general treatment for these conditions.

More about vitamin B6
More about Sore or Geographic Tongue

Other ingredients used for Sore or Geographic Tongue

Aloe vera
vitamin B12
vitamin B6
Zinc

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