Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B9 (folic acid) is primarily recognized for its essential role in DNA synthesis, cell division, and growth, processes that are especially active in the rapidly renewing cells of the small intestine’s mucosal lining. There is scientific evidence that folic acid deficiency can lead to gastrointestinal symptoms, including mucosal atrophy and malabsorption, due to impaired epithelial cell turnover. Studies in animals and humans have demonstrated that folate deficiency can cause morphological changes in the small intestine, such as villous atrophy, reduced absorptive area, and impaired nutrient absorption. Supplementation with folic acid has been shown to reverse these changes in deficiency states. However, in individuals with adequate folate status, there is limited evidence that supplemental folic acid provides additional benefit specifically for small intestine health beyond normal maintenance.

While folic acid is not traditionally used in folk medicine specifically for small intestine disorders, its scientific role in supporting the integrity and function of the intestinal mucosa is recognized, particularly in the context of deficiency. The rating reflects that while folic acid is necessary for small intestine health, there is only modest evidence for its use as a targeted therapeutic supplement for the small intestine in otherwise healthy people.

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