Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin A is scientifically validated as essential for the normal functioning of the small intestine, primarily due to its role in maintaining the integrity and function of epithelial tissues, including the mucosal lining of the gastrointestinal tract. Retinoic acid, the active form of vitamin A, supports the differentiation and maintenance of intestinal epithelial cells, which are crucial for nutrient absorption and forming a barrier against pathogens. Deficiency in vitamin A can lead to impaired mucosal barrier function, increased vulnerability to infection, and malabsorption issues. Multiple animal and human studies indicate that adequate vitamin A status improves intestinal immunity, supports mucosal repair, and modulates gut-associated lymphoid tissue. For example, research has shown that vitamin A supplementation in deficient populations reduces the incidence and severity of diarrheal diseases, which are linked to compromised small intestinal function. However, in populations with sufficient vitamin A status, additional supplementation does not appear to enhance small intestine health. In summary, there is strong scientific evidence supporting the necessity of vitamin A for the maintenance and repair of the small intestine’s epithelial lining and for supporting mucosal immunity, particularly in cases of deficiency.

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