Evidence supporting the use of: Peptides
For the body system: Small Intestines
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Peptides, particularly bioactive peptides derived from dietary proteins, have garnered scientific interest for their potential to support small intestinal health. Research indicates that certain peptides can enhance the integrity of the intestinal barrier, modulate immune responses, and promote healing of the intestinal mucosa. For example, collagen-derived peptides have been shown in animal and in vitro studies to increase the expression of tight junction proteins, thereby supporting gut barrier function and reducing intestinal permeability ("leaky gut"). Additionally, some peptides exhibit anti-inflammatory properties that may be beneficial in conditions characterized by intestinal inflammation, such as inflammatory bowel disease (IBD).
Clinical studies in humans are limited and results are somewhat variable; however, there is emerging evidence that oral supplementation with specific peptides may aid in mucosal repair and support gastrointestinal comfort, especially in populations with increased gut permeability or after injury. It is important to note that not all peptides have the same effects, and much of the research focuses on specific types (e.g., glutamine peptides, collagen peptides). While the current body of evidence is promising and supports a mechanistic role for certain peptides in small intestinal health, large-scale, robust clinical trials are still needed to confirm efficacy and clarify optimal dosing and peptide sources.
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