Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Lactobacillus is a genus of probiotic bacteria widely studied for its effects on the gastrointestinal tract, including the small intestine. Scientific evidence supports its use in maintaining and restoring a healthy balance of intestinal microbiota, which is crucial for small intestine health. Clinical trials and mechanistic studies indicate that various Lactobacillus strains can help inhibit the growth of pathogenic bacteria, modulate immune responses, and enhance barrier function in the small intestine. For example, Lactobacillus rhamnosus GG and Lactobacillus plantarum have demonstrated the ability to reduce the severity and duration of infectious diarrhea, and they may help prevent antibiotic-associated diarrhea by colonizing the small intestine and producing antimicrobial substances.

Research also suggests that Lactobacillus species can alleviate symptoms of small intestinal bacterial overgrowth (SIBO) and irritable bowel syndrome (IBS), both of which involve the small intestine. The benefits are strain-specific and not all Lactobacillus species or strains have the same effect, but the genus as a whole is well-recognized for supporting digestive health. While most probiotic research focuses on overall gut health rather than isolating effects to the small intestine alone, the evidence base is strong for certain strains, justifying a high rating for scientific support.

References: Sanders ME et al., "Probiotics and prebiotics in intestinal health and disease: from biology to the clinic," Nature Reviews Gastroenterology & Hepatology, 2019; McFarland LV, "Evidence-based review of probiotics for antibiotic-associated diarrhea and Clostridium difficile infections," World J Gastroenterol, 2010.

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