Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Lactobacillus (mixed species) is commonly used to support the health and function of the small intestine, primarily due to its role as a probiotic. Scientific research indicates that various strains of Lactobacillus can help maintain a healthy balance of intestinal microbiota, which is crucial for optimal digestion and immune regulation within the small intestine. Several randomized controlled trials and systematic reviews have demonstrated that supplementation with Lactobacillus strains (such as L. acidophilus, L. rhamnosus, and L. plantarum) can reduce symptoms of small intestinal disorders, including antibiotic-associated diarrhea, small intestinal bacterial overgrowth (SIBO), and irritable bowel syndrome (IBS).

Mechanistically, Lactobacillus species contribute to small intestine health by producing lactic acid and other metabolites that inhibit pathogenic bacteria, enhancing the integrity of the intestinal mucosal barrier, and modulating immune responses. There is growing evidence supporting their use in restoring microbiota following disruptions from antibiotics or illness. However, not all clinical trials show benefit for every individual or condition, and efficacy can be strain-specific.

In summary, the use of mixed Lactobacillus species to support the small intestine is supported by a substantial body of scientific evidence, although the degree of benefit may vary depending on the strains used and the specific health context.

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