Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Glutamine is an amino acid that is considered conditionally essential during periods of physiological stress, such as illness or injury. Its use to support the small intestine is primarily supported by scientific evidence. The cells lining the small intestine (enterocytes) utilize glutamine as a primary fuel source. Several studies, including randomized controlled trials, have shown that glutamine supplementation can help maintain the integrity of the intestinal mucosa, reduce intestinal permeability ("leaky gut"), and promote recovery in individuals experiencing gastrointestinal stress, such as after chemotherapy, radiation, or severe illness.

Glutamine has been found to support the maintenance and repair of the intestinal lining, which is critical for nutrient absorption and barrier function. Clinical applications include its use in parenteral and enteral nutrition for critically ill patients and those with inflammatory bowel diseases (IBD), short bowel syndrome, or following intestinal surgery. While most evidence comes from clinical settings involving compromised gut function, the use of glutamine for general gut health in healthy individuals is less well established, though it is still commonly recommended by some practitioners.

Overall, the scientific literature supports glutamine's role in supporting the small intestine, particularly in circumstances involving increased demand or compromised gut integrity. Evidence is strongest for clinical populations, justifying a high evidence rating.

More about Glutamine (various)
More about Small Intestines

Other ingredients that support Small Intestines

Other body systems supported by Glutamine (various)

Products containing Glutamine (various)