Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Exo-peptidases are enzymes that catalyze the removal of amino acids from the ends of peptide chains during protein digestion. Their use to support the small intestine is scientifically validated, as they play a direct role in the final stages of protein digestion within the small intestine. The pancreas secretes a variety of digestive enzymes, including both endo- and exo-peptidases, into the small intestine, where they break down dietary proteins into absorbable amino acids and small peptides. Exo-peptidases, such as carboxypeptidases and aminopeptidases, act on the terminal ends of peptides, enabling efficient nutrient absorption. Supplementing with exo-peptidases or using enzyme preparations containing them has been investigated in cases of pancreatic insufficiency or certain malabsorption disorders, showing beneficial effects in improving protein digestion and nutrient uptake. While most healthy individuals produce sufficient endogenous exo-peptidases, supplementation has a clear scientific rationale in clinical contexts involving enzyme deficiency or compromised intestinal function. Multiple studies, including randomized controlled trials and reviews, support the use of exo-peptidase-containing enzyme supplements for improving digestive outcomes in relevant populations. Therefore, the use of exo-peptidase to support the small intestine is based on scientific principles and evidence, particularly in the context of digestive enzyme therapy.

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