Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Carvacrol is a monoterpenoid phenol found in oregano oil and thyme, and has been studied for its antimicrobial and anti-inflammatory properties, including potential benefits for the gastrointestinal tract. Scientific research demonstrates that carvacrol exhibits broad-spectrum antimicrobial activity against various pathogenic bacteria and fungi, some of which are implicated in small intestinal bacterial overgrowth (SIBO) and other gut dysbiosis conditions. Several in vitro studies and animal models have shown that carvacrol can inhibit the growth of Escherichia coli, Salmonella, Staphylococcus aureus, and Candida albicans, among others. There is also evidence that carvacrol may reduce intestinal inflammation and modulate gut microbiota composition, possibly supporting small intestine health and integrity.

However, while these results are promising, most of the data come from laboratory or animal studies, with a paucity of well-controlled clinical trials in humans specifically evaluating carvacrol’s effects on the small intestine. Its use in supporting the small intestine in humans is therefore mainly extrapolated from these preclinical findings rather than direct human evidence. As a result, carvacrol is rated as having moderate (3/5) scientific evidence for supporting the small intestine—there is biological plausibility and laboratory support, but robust human clinical validation is still lacking.

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