Vitamin B6 (pyridoxine) has been investigated for its potential role in supporting sleep, particularly in managing restless or disturbed sleep. The scientific interest stems from vitamin B6’s involvement in the synthesis of neurotransmitters such as serotonin and melatonin, both of which are critical regulators of mood and sleep-wake cycles. Some small studies and clinical trials have suggested that vitamin B6 supplementation may improve certain aspects of sleep quality, likely due to its role in increasing the body’s production of serotonin, which is then converted to melatonin, the hormone that regulates sleep.

For example, a small randomized controlled trial in 2018 found that a combination of vitamin B6 and magnesium improved self-reported measures of insomnia in elderly subjects. Another study from the 1970s reported that vitamin B6 supplementation increased dream vividness and recall, suggesting an impact on REM sleep. However, direct evidence supporting vitamin B6 as a monotherapy for sleep disturbances is limited, and results across studies are mixed, with some finding no significant benefit.

Overall, while there is a plausible biological mechanism and some supportive evidence, the quality and quantity of clinical research are not robust enough to strongly validate vitamin B6 as a primary treatment for restless or disturbed sleep. As such, its use may be considered adjunctive rather than primary, and further well-designed studies are needed.