Evidence supporting the use of: Hyaluronidase
For the health condition: Skin (infections)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hyaluronidase is an enzyme that breaks down hyaluronic acid in the extracellular matrix, increasing tissue permeability and facilitating the diffusion of fluids and injected drugs. Its use in relation to skin infections is not as a direct antimicrobial agent, but as an adjunct to enhance the effectiveness of other treatments. Historically, hyaluronidase has been used to promote the dispersion and absorption of antibiotics and other injected medications in the management of cellulitis, abscesses, and other localized skin infections. Several clinical guidelines and studies support its role in facilitating the spread of antibiotics through infected tissues, especially in cases where edema or dense connective tissue may limit drug penetration.

For example, a review in Drugs (2004) and various infectious disease texts document its adjunctive use in treating cellulitis and other soft tissue infections, particularly when rapid spread or compartmentalization of infection is a concern. Evidence supporting this approach is moderate, primarily from case series and older clinical experience; randomized controlled trials are limited. Modern use is less common due to advances in systemic antibiotics and improved wound care, but hyaluronidase remains a tool in specific clinical scenarios, such as when rapid drug dispersion is desired or when treating extravasation injuries. Overall, while not a first-line treatment for skin infections, its role as a facilitator for drug diffusion is supported by moderate scientific evidence.

More about Hyaluronidase
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Products containing Hyaluronidase

We currently have no products on Caring Sunshine that contain this ingredient.