Evidence supporting the use of: Goldenseal
For the health condition: Skin (infections)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Goldenseal (Hydrastis canadensis) has a long history of traditional use among Native American tribes and later in Western herbal medicine, particularly as a topical agent for skin infections and wounds. The plant’s roots contain several alkaloids, most notably berberine, which is known for its antimicrobial properties. Historically, goldenseal was applied as a poultice or wash to treat skin ailments such as ulcers, sores, and minor wounds, with records of use spanning back centuries. This traditional application was based on empirical knowledge and observation rather than scientific trials.

While laboratory studies have confirmed that berberine and other constituents of goldenseal exhibit antimicrobial activity against various bacteria and fungi in vitro, there is a notable lack of robust clinical trials specifically evaluating the efficacy of goldenseal for skin infections in humans. The available scientific evidence mainly consists of test tube studies, animal research, and anecdotal reports, rather than randomized controlled trials. As a result, goldenseal's use for skin infections today is still primarily rooted in traditional practice, supported by some plausible biological mechanisms but without strong clinical validation. Caution is advised, as topical use may cause irritation or allergic reactions in some individuals.

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azelaic acid
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benzoin
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burning bush
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camphor oil
Casearia esculenta
castile soap
Cedrus libani
chaparral
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chickweed
Chiococca alba
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Chondracanthus chamissoi
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cocklebur
copaiba oil
copper
croton seeds
Cynodon dactylon
cypress
daphne
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Echinodorus
emu oil
farnesol
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fleabane
frankincense
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gallic acid
genipap
geranial
geraniol
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golden shower tree
goldenrod
goldenseal
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heartwood
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hydroxyquinoline
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knotweed
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