Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glyceryl caprylate caprate is primarily recognized as an emulsifier, co-emulsifier, and skin conditioning agent in topical formulations. However, there is some scientific evidence to support its use for skin infections due to its antimicrobial properties. Glyceryl caprylate and glyceryl caprate are mono- and diesters of glycerol with caprylic (C8) and capric (C10) fatty acids, respectively. Studies have demonstrated that these medium-chain fatty acid derivatives possess activity against a range of microorganisms, including Staphylococcus aureus and Malassezia species, both of which are common culprits in skin infections. For example, a 2019 in vitro study found that glyceryl caprylate exhibited significant inhibitory effects against Malassezia yeasts, which are implicated in conditions such as seborrheic dermatitis and dandruff. Other research indicates that glyceryl caprylate can disrupt bacterial cell membranes, leading to reduced microbial viability.

Despite these findings, clinical studies directly supporting the use of glyceryl caprylate caprate as a treatment for skin infections in humans are limited. Its antimicrobial effects are mostly demonstrated in laboratory settings or as an adjunct to preservative systems in cosmetics. Therefore, while there is some scientific validation for its antimicrobial action, the strength of evidence for its use specifically for treating skin infections is modest, justifying a rating of 2 out of 5.

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