Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Aureobasidium pullulans is a black yeast-like fungus primarily known for its industrial applications, such as the production of pullulan, a polysaccharide used in food and pharmaceuticals. In recent years, there has been growing scientific interest in its potential biomedical uses, including the support and treatment of skin infections. Some strains of A. pullulans produce antimicrobial compounds, such as aureobasidin A and related metabolites, which have demonstrated activity against certain pathogenic bacteria and fungi in vitro. Additionally, pullulan itself has film-forming and moisture-retaining properties, making it a useful ingredient in wound dressings and skin care formulations.

However, the direct clinical evidence supporting the use of A. pullulans or its metabolites for treating skin infections in humans is limited. Most available studies are preclinical, including laboratory and animal models, and focus on antimicrobial activity or wound-healing support rather than direct treatment of established skin infections. There are no robust human clinical trials to date demonstrating efficacy in this context. Therefore, while there is a scientific basis for further investigation, the current level of evidence is modest and largely preliminary.

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