Evidence supporting the use of: Vitamin E
For the health condition: Skin (dry and/or flaky)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin E is widely used in dermatology for its antioxidant properties and its role in skin barrier function. Scientific evidence supports its topical use for improving skin hydration and reducing dryness and flakiness. Vitamin E (tocopherol) acts as a lipid-soluble antioxidant, protecting cell membranes from oxidative damage caused by free radicals, which can contribute to skin dryness and accelerated aging. Studies have shown that topical application of vitamin E can improve both skin moisture content and tactile roughness, particularly in individuals with dry or compromised skin barriers. Some clinical trials and in vitro studies suggest that vitamin E enhances the skin’s water-binding capacity and helps maintain the integrity of the stratum corneum, which is essential for healthy, hydrated skin.

Oral vitamin E supplementation, however, shows less consistent benefits for skin dryness, as systemic absorption does not always result in increased skin concentrations. While vitamin E is included in numerous creams and lotions, evidence for its efficacy in treating severely flaky or pathological dry skin (such as in eczema or psoriasis) is less robust, and it is usually recommended as a supportive, rather than primary, treatment. Nonetheless, the dermatological community recognizes vitamin E’s supportive role, especially in combination with other moisturizing agents. Its safety profile and antioxidant benefits have contributed to its popularity in traditional and commercial skin care products. Overall, there is moderate scientific validation for the use of topical vitamin E in supporting dry and flaky skin.

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