Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Aloe polysaccharides, especially acemannan, are bioactive compounds extracted from the inner gel of the Aloe vera plant. Their use in supporting dry and/or flaky skin is primarily justified by scientific evidence, though the quality and amount of supporting research is moderate. Several in vitro and clinical studies suggest that Aloe polysaccharides enhance skin hydration by forming a protective barrier on the skin’s surface and stimulating fibroblast activity, which increases collagen and hyaluronic acid synthesis. These effects contribute to improved moisture retention and skin repair.

A 2006 double-blind randomized controlled trial published in the Annals of Dermatology found that oral administration of Aloe vera gel increased skin hydration and reduced wrinkle depth in women over 45. Another study in the Journal of Ethnopharmacology (2003) showed that topical Aloe gel improved symptoms of dry and irritated skin, likely due to the moisturizing effects of its polysaccharide components. Polysaccharides are believed to bind water and interact with skin proteins, reinforcing the skin barrier and decreasing TEWL (transepidermal water loss).

While these studies support the efficacy of Aloe polysaccharides for managing dry or flaky skin, limitations include small sample sizes and variability in Aloe preparations. Therefore, while scientific evidence exists, it is not unequivocal, and further large-scale studies are needed to establish standardized dosing and confirm long-term benefits.

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