Grapeseed oil is widely used in skin care due to its high content of polyunsaturated fatty acids (primarily linoleic acid), vitamin E, and various phytochemicals. Scientific studies support its use for general skin care, especially in regard to its moisturizing, antioxidant, and anti-inflammatory properties. Research has shown that topical application of grapeseed oil can improve skin barrier function and hydration, particularly for individuals with dry or compromised skin. Linoleic acid, abundant in grapeseed oil, has been demonstrated in studies to benefit the skin barrier and reduce trans-epidermal water loss.

Additionally, grapeseed oil contains proanthocyanidins, potent antioxidants that may protect the skin from oxidative stress caused by ultraviolet (UV) radiation and pollution. Some in vitro and animal studies have indicated that components in grapeseed oil can aid wound healing and reduce inflammation. While there is promising laboratory and small-scale clinical evidence, large, high-quality human trials are limited. Grapeseed oil is considered non-comedogenic and is generally safe for most skin types when used topically.

In summary, the use of grapeseed oil for general skin care is supported by scientific evidence regarding its moisturizing and antioxidant effects, though more extensive clinical trials would strengthen these claims further.