Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Catalase is an enzyme that catalyzes the decomposition of hydrogen peroxide into water and oxygen, protecting cells from oxidative damage. In skin care, its use is primarily justified by scientific rationale, though the direct clinical evidence in humans is still limited. Catalase is incorporated into some topical products for its antioxidant properties, aiming to combat oxidative stress caused by environmental factors such as UV radiation and pollution. Scientific studies have shown that catalase can reduce oxidative damage in vitro (in laboratory settings) and in animal models. By breaking down hydrogen peroxide, catalase helps prevent the formation of reactive oxygen species (ROS), which can lead to premature skin aging and cellular damage. Some studies have demonstrated that topical application of catalase, particularly when combined with other antioxidants, can reduce markers of oxidative stress in skin cells. However, clinical trials evaluating the effectiveness of catalase-containing skin care products in humans are sparse. There are issues surrounding the enzyme's stability and penetration through the skin barrier. Many formulations use encapsulation technologies (such as liposomes) to attempt to deliver catalase effectively to deeper skin layers, but robust, peer-reviewed clinical data demonstrating significant benefits in anti-aging or general skin health are lacking. In summary, while the biochemical rationale for catalase use in skin care is strong and supported by laboratory research, direct evidence from human clinical trials remains limited, resulting in a moderate evidence rating.

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