Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin K is scientifically validated as an important nutrient for bone health and maintenance of the skeletal system. Vitamin K exists in multiple forms, primarily K1 (phylloquinone) and K2 (menaquinones). Research indicates that Vitamin K functions as a cofactor for the enzyme gamma-glutamyl carboxylase, which is essential for the activation of osteocalcin, a protein produced by osteoblasts that binds calcium in the bone matrix. Deficiency in Vitamin K can lead to undercarboxylated osteocalcin, which is less effective in binding calcium, potentially resulting in decreased bone mineral density and increased fracture risk.

Several epidemiological and clinical studies support the role of Vitamin K—particularly K2—in reducing bone loss and fracture risk, especially in postmenopausal women. A 2017 meta-analysis in the journal Osteoporosis International found that Vitamin K2 supplementation was associated with improved bone mineral density and reduced fracture rates. While Vitamin K1 is primarily involved in blood clotting, it also contributes to bone health, though evidence is stronger for K2.
Guidelines in some countries (e.g., Japan) recommend Vitamin K2 for osteoporosis management. However, while results are promising, not all studies have shown consistent benefits, and more large-scale randomized controlled trials are needed for conclusive evidence.

In summary, the use of mixed Vitamin K forms to support skeletal health is scientifically justified, with a substantial but not absolute body of evidence supporting its efficacy, especially for Vitamin K2.

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