Evidence supporting the use of: Vitamin K
For the body system: Skeletal System (Bones)
Synopsis
Source of validity: Scientific
Rating (out of 5): 4
Vitamin K is scientifically validated as important for bone health. Vitamin K, particularly K2 (menaquinone), is involved in the carboxylation of osteocalcin, a protein that binds calcium in bones and is essential for bone mineralization. Several observational studies and randomized controlled trials have found that adequate vitamin K intake is associated with higher bone mineral density and reduced fracture risk, especially in postmenopausal women. Meta-analyses have concluded that vitamin K supplementation can modestly increase bone mineral density and may reduce fracture incidence, though the effects are more pronounced in populations with low baseline vitamin K status or at higher risk of osteoporosis.
Mechanistically, vitamin K is necessary for the activation of bone matrix proteins and helps regulate calcium deposition, preventing it from accumulating in arteries and instead directing it to bones. The Institute of Medicine and numerous clinical guidelines recognize the role of vitamin K in bone metabolism, though they do not universally recommend supplementation unless deficiency is present. While more research is needed to fine-tune dosing and population benefit, the scientific consensus is that vitamin K is a valid and important nutrient for skeletal health.
Other ingredients that support Skeletal System (Bones)
AchyranthesAlfalfa
Algae
Algas calcareas
alpha-ketoglutarate (AKG)
amino acids
animal protein
antler
arugula
baicalein
beef
bone marrow
bone protein
boneset
boron
Boswellia
Boswellic Acid
bovine
bovine cartilage / glycosaminoglycan
bovine protein
broccoli
Buckwheat
calcium
cartilage
Chinese mountain ant
Chinese pond turtle
Chinese salvia root
Chinese silkvine
chondroitin
chuchuhuasi
Cissus quadrangularis
citrate malate
cod liver oil
collagen
collard
comfrey
Corallina officinalis
cruciferous
daidzein
deer velvet
devil's claw
Dipsacus
dolomite
Drynaria
egg
elk antler
estrogen
eucommia
Eucommia ulmoides
fibroblast growth factor
fish
fish protein
Foxtail millet
fructoborate
genistein
genistin
Glycosaminoglycans
green-lipped mussel
herbal blend (proprietary)
HMB hydroxymethylbutyrate
horse gram
horsetail
hydroxyproline
icariin
Indian frankincense
ipriflavone
isoflavones
Kaempferol
Ledebouriella
Legume protein
Lithothamnion
magnesium
manganese
Microcrystalline hydroxyapatite concentrate (MCHC)
Milk
Milk Protein
Mineral blend
Molasses
Osthole
Peptides
phosphorus
Phytoestrogens
Polygonatum
protein
proteoglycans
prune
Rehmannia
rehmannia glutinosa
seaweed
sesame
Shilajit
silicon
Sinomenium acutum
solomon's seal
Soy
soy isoflavones
Soy Protein
Spatholobus
spinach
strontium
Taxillus chinensis
Taxillus sutchuenensis
trace minerals
vitamin C
vitamin D
vitamin D3
vitamin K
Other body systems supported by vitamin K
ArteriesBlood
Capillaries
Circulatory System
Gums
Heart
Skeletal System (Bones)
Structural System
Teeth
