Evidence supporting the use of: Vitamin K
For the body system: Skeletal System (Bones)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin K is scientifically validated as important for bone health. Vitamin K, particularly K2 (menaquinone), is involved in the carboxylation of osteocalcin, a protein that binds calcium in bones and is essential for bone mineralization. Several observational studies and randomized controlled trials have found that adequate vitamin K intake is associated with higher bone mineral density and reduced fracture risk, especially in postmenopausal women. Meta-analyses have concluded that vitamin K supplementation can modestly increase bone mineral density and may reduce fracture incidence, though the effects are more pronounced in populations with low baseline vitamin K status or at higher risk of osteoporosis.

Mechanistically, vitamin K is necessary for the activation of bone matrix proteins and helps regulate calcium deposition, preventing it from accumulating in arteries and instead directing it to bones. The Institute of Medicine and numerous clinical guidelines recognize the role of vitamin K in bone metabolism, though they do not universally recommend supplementation unless deficiency is present. While more research is needed to fine-tune dosing and population benefit, the scientific consensus is that vitamin K is a valid and important nutrient for skeletal health.

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