Evidence supporting the use of: Vitamin D3
For the body system: Skeletal System (Bones)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Vitamin D3 (cholecalciferol) is scientifically validated in its role supporting the skeletal system, particularly bone health. Vitamin D3 is essential for calcium absorption in the intestines, which is critical for maintaining proper bone mineralization and strength. Deficiency in vitamin D3 leads to impaired bone mineralization, resulting in conditions such as rickets in children and osteomalacia or osteoporosis in adults. Multiple randomized controlled trials and meta-analyses have demonstrated that adequate vitamin D3 intake, often in combination with calcium, reduces bone loss and fracture risk, especially in older adults.

Regulatory bodies such as the Institute of Medicine (now the National Academy of Medicine) and the Endocrine Society recognize vitamin D’s central role in bone health, recommending supplementation in cases of deficiency or limited sun exposure. The robust scientific consensus is reflected in clinical guidelines worldwide. Furthermore, vitamin D receptors are present in bone cells (osteoblasts and osteoclasts), and vitamin D3 directly influences bone remodeling processes.

In summary, the use of vitamin D3 to support the skeletal system is supported by high-quality scientific evidence and is a standard medical practice for preventing and treating bone disorders related to vitamin D deficiency.

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