Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Soy isoflavones, particularly genistein and daidzein, are phytoestrogens—plant-derived compounds that can weakly mimic estrogen in the body. Estrogen is known to play a critical role in maintaining bone density, especially in postmenopausal women who are at higher risk for osteoporosis due to declining estrogen levels. Several clinical studies and meta-analyses have investigated the effect of soy isoflavones on bone health. For example, a 2019 meta-analysis published in Osteoporosis International reported that soy isoflavone supplementation modestly increased bone mineral density (BMD) at the lumbar spine in postmenopausal women compared to placebo, although the effect at the hip was less clear. The proposed mechanism involves isoflavones binding to estrogen receptors in bone, reducing bone resorption and potentially supporting bone formation. However, while results are generally positive, the magnitude of the benefit is modest, and some studies show little to no effect. The safety profile of soy isoflavones is generally regarded as good, but long-term effects are still under investigation. In summary, there is scientific support for the use of soy isoflavones to help maintain bone health, especially in postmenopausal women, but the evidence is moderate rather than strong, and soy isoflavones should not replace established osteoporosis treatments when those are indicated.

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