Peptides, particularly collagen peptides, have garnered significant scientific interest for their potential to support the skeletal system, especially bone health. Collagen is a primary structural protein in bones, providing a framework for mineralization and contributing to bone strength and flexibility. Hydrolyzed collagen peptides are easily absorbed in the gastrointestinal tract and have been shown in several clinical and preclinical studies to positively influence bone metabolism.

Research indicates that collagen peptide supplementation can increase bone mineral density (BMD) and stimulate the production of bone-forming cells (osteoblasts) while reducing the activity of bone-resorbing cells (osteoclasts). For instance, a randomized controlled trial published in 2018 found that postmenopausal women who consumed collagen peptides daily for 12 months experienced a significant increase in BMD compared to placebo. Additionally, in vitro and animal studies suggest collagen peptides may enhance the synthesis of bone matrix proteins and improve bone microarchitecture.

While more large-scale, long-term human studies are needed to fully establish efficacy, current evidence supports the use of specific peptides (notably collagen peptides) as a scientifically validated option to help maintain or improve bone health, particularly in populations at risk of osteoporosis or bone loss.