Evidence supporting the use of: Manganese
For the body system: Skeletal System (Bones)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Manganese is a trace mineral that plays a significant role in bone health, providing scientific justification for its use in supporting the skeletal system. Biochemically, manganese is a cofactor for several enzymes involved in bone formation, including glycosyltransferases, which are required for the synthesis of proteoglycans that form the organic matrix of bone. Studies in animal models have shown that manganese deficiency leads to impaired bone growth, skeletal deformities, and reduced bone mineral density. In humans, observational studies suggest a correlation between adequate manganese intake and bone health, and low manganese levels have been associated with decreased bone mineral density in postmenopausal women. However, strong interventional data in humans are limited. While some small studies have included manganese as part of multi-mineral supplements (often with calcium, zinc, and copper) and shown modest improvements in bone markers or density, the individual contribution of manganese alone is less clear. The Institute of Medicine recognizes manganese as an essential nutrient for bone health, but deficiency is rare in healthy individuals consuming a typical diet. Overall, manganese's role in supporting the skeletal system is scientifically valid, but the strength of the evidence is moderate, justifying a rating of 3.

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