Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Manganese sulfate is a source of the essential trace mineral manganese, which plays a critical role in bone health. Scientifically, manganese is required as a cofactor for several enzymes involved in the formation of bone and connective tissue, including glycosyltransferases that participate in the synthesis of proteoglycans—important components of the bone matrix. Research has shown that manganese deficiency can lead to impaired bone formation, decreased bone mineral density, and skeletal deformities in animal studies. In humans, while outright manganese deficiency is rare due to its presence in a wide variety of foods, inadequate intake could potentially contribute to suboptimal bone health, especially in populations with poor diets.

Clinical studies in humans have found associations between manganese status and bone mineral density, but direct evidence from supplementation trials is limited and not always consistent. Manganese, usually in combination with calcium, zinc, and other nutrients, is sometimes included in supplements aimed at supporting bone health, such as those for osteoporosis prevention. The scientific rationale for its inclusion is based on its known physiological functions rather than robust clinical outcomes. Therefore, while there is a scientific basis for manganese sulfate’s role in bone health, the direct evidence in humans for supplementation is moderate, meriting a rating of 3 out of 5.

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