Manganese is an essential trace mineral required for normal bone development and maintenance. It acts as a cofactor for enzymes involved in the formation of bone cartilage and collagen, both of which are crucial for skeletal health. Scientific evidence shows that manganese deficiency in animals and humans can lead to impaired bone growth and skeletal abnormalities. The form "Manganese Alpha-Ketoglutarate" is a chelated compound, theoretically designed to enhance manganese absorption, though specific studies on this exact compound in relation to bone health are limited.

Several studies have demonstrated that adequate manganese intake supports bone mineral density and proper formation of the organic bone matrix. For example, manganese is necessary for the activity of glycosyltransferases, enzymes that synthesize proteoglycans, key components of bone and cartilage. The National Institutes of Health and other reputable sources acknowledge manganese’s role in skeletal health, though they also note that manganese deficiency is rare in humans.

While there is scientific consensus on the importance of manganese for bone health, direct clinical research on manganese supplementation (and specifically manganese alpha-ketoglutarate) for preventing or treating bone diseases in humans is limited. Therefore, the evidence is moderate (3/5): based on the established biological role of manganese, but with few intervention studies confirming benefits of supplemental forms in individuals without deficiency.