Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Isoflavones, particularly those found in soy, have been the subject of scientific research regarding their potential benefits for bone health, especially in postmenopausal women. Isoflavones are phytoestrogens—plant-derived compounds that can mimic estrogen in the body. Since estrogen plays a critical role in maintaining bone density, the decline in estrogen levels after menopause is associated with increased risk of osteoporosis. Several clinical trials and meta-analyses suggest that isoflavone supplementation may help reduce bone loss and improve bone mineral density (BMD), primarily in postmenopausal women. For example, a 2015 meta-analysis published in Osteoporosis International found that soy isoflavone supplementation was associated with a modest increase in BMD at the lumbar spine.

However, the overall magnitude of benefit is generally considered small, and not all studies have found significant effects. The variability in outcomes may be due to differences in study design, population, dosage, and the form of isoflavones used. While isoflavones are not considered a replacement for established osteoporosis treatments, there is moderate scientific support for their role as a complementary approach to supporting bone health, especially in populations at risk due to low estrogen levels.

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