Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Fibroblast growth factors (FGFs) are a family of proteins that play a crucial role in bone development, maintenance, and repair. Scientific studies have validated their importance in skeletal biology. FGFs, particularly FGF2, are involved in the regulation of osteoblast proliferation and differentiation, which are essential processes for bone formation and remodeling. Mutations in FGF receptors (such as FGFR2 and FGFR3) are known to cause various skeletal disorders, including craniosynostosis and achondroplasia, highlighting the critical role of FGFs in normal bone growth and development.

Preclinical research shows that administration of certain FGFs can enhance bone healing in animal models, and there is ongoing research into their potential therapeutic applications for treating bone defects and fractures. For example, FGF2 has been demonstrated to stimulate bone formation in vitro and in vivo by promoting the proliferation of bone-forming cells and increasing the expression of bone matrix proteins.

While FGFs themselves are not widely used as direct therapeutic agents in clinical practice for skeletal disorders due to delivery challenges and potential side effects, their biological effects are well-characterized, and they remain a focus of regenerative medicine research. Overall, the role of FGFs in supporting the skeletal system is strongly supported by scientific evidence from both genetic studies and experimental models.

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