Calcium fructoborate is a naturally occurring boron-containing compound found in some fruits and vegetables. It has been studied for its potential benefits to the skeletal system, particularly in bone health and joint function. The scientific interest in calcium fructoborate stems from boron's established role in bone metabolism; boron is involved in the metabolism of minerals such as calcium, magnesium, and phosphorus, which are vital for bone structure and strength.

Several small-scale human clinical trials and animal studies have investigated calcium fructoborate’s effects. Some studies suggest supplementation can reduce inflammation markers and improve joint comfort, while others report modest benefits in bone health, such as increased bone mineral density or improved biochemical markers of bone turnover. However, these studies often have methodological limitations, such as small sample sizes, short durations, or lack of long-term follow-up.

Systematic reviews and meta-analyses have concluded that while there is some preliminary evidence supporting calcium fructoborate’s role in supporting bone health, the overall quality and quantity of evidence is limited. Larger, well-designed clinical trials are needed to establish its efficacy and safety for skeletal support. Thus, its use is partially scientifically justified, but the evidence remains moderate at best.