Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bovine-derived ingredients, particularly bovine bone and cartilage, are used in supplements intended to support the skeletal system due to their content of minerals (such as calcium and phosphorus), collagen, and other growth factors. Scientific evidence supports the use of bovine bone extracts as a source of bioavailable calcium and collagen, both essential for bone health. Hydrolyzed bovine collagen, for instance, has been shown in some clinical studies to promote bone mineral density and improve markers of bone formation, especially in postmenopausal women and individuals at risk for osteoporosis. The mechanism involves the supply of amino acids necessary for collagen synthesis, which is crucial for bone matrix structure and strength. Bovine bone meal, once popular as a calcium source, has declined in use due to safety concerns (notably bovine spongiform encephalopathy), but purified forms are still available. However, while there is moderate evidence that bovine collagen peptides can positively affect bone health, the effect sizes are typically modest, and not all studies show strong benefits. The overall quality of evidence is limited by small sample sizes and study durations. Therefore, while bovine-derived ingredients do have scientific support for supporting skeletal health, they should not be considered replacements for established bone health strategies such as sufficient dietary calcium, vitamin D, and weight-bearing exercise.

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