Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Bone protein refers primarily to a group of proteins—most notably collagen, but also non-collagenous proteins like osteocalcin and bone morphogenetic proteins (BMPs)—that are naturally present in the bone matrix. Scientific evidence supports the role of these proteins in bone health and skeletal system support. Collagen, the most abundant protein in bone, provides a structural framework, contributing to bone’s tensile strength and flexibility. Hydrolyzed collagen supplements, derived from bovine or marine sources, have been shown in clinical trials to improve bone mineral density and stimulate osteoblast (bone-forming cell) activity. Additionally, bone morphogenetic proteins (BMPs), especially BMP-2 and BMP-7, are well-studied in orthopedics for their ability to promote new bone formation and healing, particularly in bone grafts and spinal fusions.

Human and animal studies have demonstrated that supplementation with bone-derived proteins or peptides can improve markers of bone turnover, increase bone mass, and potentially reduce fracture risk in populations at risk for osteoporosis. The scientific consensus is not absolute, and more long-term, large-scale studies are needed to define optimal dosages and populations who benefit most. However, the use of bone protein to support skeletal health is rooted in both an understanding of bone biology and empirical clinical research, making its use scientifically justified.

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