Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Purple butterbur root (Petasites hybridus) has been traditionally used in Europe for various ailments, but its use for supporting the sinus body system—particularly in the context of allergic rhinitis and sinus congestion—has also been investigated in scientific studies. Several double-blind, placebo-controlled trials have examined standardized butterbur extracts (such as Ze 339) in patients with allergic rhinitis, which often involves sinus symptoms. These studies have shown that butterbur extract can reduce symptoms such as nasal congestion, sneezing, and itchy eyes, with efficacy comparable to some antihistamines but with fewer sedative effects. The proposed mechanism involves inhibition of leukotriene synthesis, which plays a role in inflammation and allergic responses. However, it is important to note that raw butterbur contains pyrrolizidine alkaloids (PAs), which can be toxic to the liver, so only PA-free extracts should be used. The body of evidence is moderate, with multiple randomized controlled trials but with some limitations in study size and duration. Thus, while butterbur root is supported by scientific evidence for sinus-related symptoms, the rating reflects the need for more extensive and longer-term studies to confirm its safety and efficacy.

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