Plantain (Plantago major), a common herbaceous plant, has a long history of traditional use in supporting respiratory health, including the sinuses. In traditional European and Native American herbal medicine, plantain leaves have been used as a remedy for coughs, bronchitis, and other respiratory complaints. The mucilage content in plantain is believed to soothe irritated mucous membranes, while its mild anti-inflammatory properties may help reduce swelling in the nasal passages and sinuses. Some historical texts and herbalists have recommended plantain infusions or teas for sinus discomfort, congestion, or general upper respiratory support.

However, scientific studies specifically examining plantain's effects on the sinuses are limited. Most available research focuses on its general anti-inflammatory and wound-healing properties, or its use for cough and throat irritation. There are some in vitro and animal studies suggesting that plantain extracts may exhibit antimicrobial and anti-inflammatory actions, which could theoretically benefit sinus health by reducing inflammation or infection risk. Despite this, clinical trials in humans targeting sinus conditions are lacking, and therefore the evidence remains largely traditional and anecdotal rather than scientifically validated.