Evidence supporting the use of: Quercetin
For the health condition: Sinus Infection

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin is a plant flavonoid found in many fruits, vegetables, and grains, and is often marketed as a supplement for supporting immune function and reducing inflammation. Its use in sinus infections (sinusitis) is primarily supported by its anti-inflammatory and antihistamine properties, which may help to reduce sinus congestion and inflammation. Several laboratory (in vitro) and animal studies have shown that quercetin can inhibit the production and release of histamines and pro-inflammatory cytokines, which play roles in the symptoms of sinusitis. For example, quercetin stabilizes mast cells, thereby reducing histamine release, and it may decrease nasal mucosa swelling.

However, clinical evidence in humans is sparse. A few small pilot studies and preliminary trials suggest that quercetin supplementation could reduce symptoms of allergic rhinitis (which shares some features with sinusitis), but direct studies on acute or chronic sinus infections are lacking. Most of the supportive data are extrapolated from its effects on inflammation and allergy symptoms rather than from trials specifically targeting sinus infection treatment or prevention. Thus, while the mechanism is plausible and supported by laboratory evidence, robust human clinical trials are needed to confirm its efficacy for sinus infections. At present, quercetin may be considered as a supportive measure, but not a primary treatment, for sinus infection symptoms.

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