Evidence supporting the use of: Tromethamine
For the health condition: Shock
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Tromethamine (also known as THAM or tris-hydroxymethyl aminomethane) is a non-CO2-generating buffer used in the management of metabolic acidosis, which can occur during various forms of shock, such as septic or cardiogenic shock. The rationale for its use is based on its ability to accept protons and thus buffer excess acid in the bloodstream, thereby helping to correct acid-base imbalances that are commonly seen in shock states. Unlike sodium bicarbonate, tromethamine does not produce carbon dioxide as a byproduct, which can be advantageous in patients with compromised ventilation or respiratory function.
Scientific evidence for tromethamine's efficacy in treating acidosis associated with shock consists mainly of small clinical studies, case reports, and animal experiments. Some studies have demonstrated that tromethamine can effectively raise blood pH and improve hemodynamic parameters. However, larger randomized controlled trials are lacking, and there are concerns regarding potential side effects, including hypoglycemia, hyperkalemia, and tissue irritation. Most major clinical guidelines do not recommend routine use of tromethamine for shock-related acidosis due to limited evidence and potential risks, often favoring supportive care and treatment of the underlying cause of shock.
In summary, while there is a scientific rationale and some supporting evidence for the use of tromethamine in the treatment of acidosis during shock, the overall quality and quantity of evidence are moderate at best, and its use remains somewhat controversial and limited to specific scenarios.
Other ingredients used for Shock
magnesiumvitamin C
electrolytes blend (proprietary)
Aconite
Albumin
catecholamine
dextran
salt
Tromethamine