Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Catecholamines (such as epinephrine, norepinephrine, and dopamine) are cornerstone agents in the management of shock, particularly in acute settings like septic, cardiogenic, and anaphylactic shock. Their use is firmly supported by a robust body of scientific evidence and is codified in international clinical guidelines. Catecholamines act primarily as vasopressors and inotropes, increasing blood pressure and cardiac output by stimulating adrenergic receptors. For example, norepinephrine is recommended as the first-line vasopressor for septic shock in the Surviving Sepsis Campaign guidelines (Evans et al., 2021). Multiple randomized controlled trials and meta-analyses have demonstrated that catecholamines effectively restore perfusion and improve hemodynamics in various shock states, although their impact on mortality can vary depending on context and agent.

While risks such as arrhythmias and tissue ischemia exist, the benefits of catecholamines in acute shock resuscitation are clear and well documented in the literature (De Backer et al., 2010; Annane et al., 2018). Their role is not based on tradition alone but is the result of decades of clinical research, pharmacological understanding, and outcome studies. Thus, the use of catecholamines in shock is scientifically validated and represents the standard of care in emergency and critical care medicine.

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