Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Adrenaline (also known as epinephrine) is scientifically validated for use in certain types of shock, particularly anaphylactic shock and as a vasopressor in cardiac arrest. In cases of anaphylaxis, adrenaline is the first-line treatment and acts by stimulating alpha and beta-adrenergic receptors. This stimulation results in vasoconstriction (which counteracts hypotension), bronchodilation (relieving airway obstruction), and inhibition of further mediator release from mast cells. The efficacy of adrenaline in anaphylactic shock is firmly established by clinical trials, observational studies, and decades of clinical experience, and it is recommended in national and international guidelines (e.g., World Allergy Organization, American Heart Association).

In other forms of shock, such as septic shock, adrenaline may be used as a second-line vasopressor when other agents (like norepinephrine) are insufficient, according to guidelines (e.g., Surviving Sepsis Campaign). Its use in cardiogenic or hypovolemic shock is more limited due to potential adverse effects (e.g., arrhythmias, increased myocardial oxygen demand), but it can be lifesaving in specific scenarios.

Overall, the use of adrenaline in shock is strongly supported by robust scientific evidence, especially for anaphylactic and cardiac arrest-related shock. Its role in other types of shock is more nuanced and typically reserved for refractory cases. Thus, its use is justified by a high level of scientific validation.

More about Adrenaline
More about Shock

Other ingredients used for Shock

Other health conditions supported by Adrenaline

Products containing Adrenaline