Synopsis

Source of validity: Scientific
Rating (out of 5): 2

D-Aspartic Acid (DAA) is a non-essential amino acid that has gained popularity as a dietary supplement, particularly for its purported effects on testosterone levels and, by extension, sex drive (libido). The scientific rationale for its use is based on research suggesting that DAA plays a role in the regulation of testosterone synthesis in the testes and the release of hormones in the hypothalamus and pituitary gland. Some early short-term studies in healthy men and infertile males have shown that DAA supplementation (typically 2-3 grams daily) can modestly increase testosterone levels, which may influence libido. For example, a 2009 study (Topo et al.) found increased testosterone after 12 days of supplementation.

However, more recent, larger, and longer-term studies in healthy, resistance-trained men have failed to replicate these effects, finding no significant increase in testosterone or improvement in sexual function with DAA supplementation. The evidence is therefore mixed: while there is some scientific basis for DAA’s role in hormone regulation, the overall quality, size, and consistency of the evidence supporting its use for enhancing sex drive in healthy men is limited. There is no substantial traditional or historical use of DAA for this purpose. Thus, DAA is used to support sex drive primarily due to preliminary scientific findings, but the evidence remains weak and inconsistent.

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