Evidence supporting the use of: Vitamin B6 (pridoxal 5-phosphate)
For the body system: Serotonin

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B6, particularly in its active form pyridoxal 5'-phosphate (PLP), is scientifically recognized for its role in the synthesis of neurotransmitters, including serotonin. PLP serves as a coenzyme for aromatic L-amino acid decarboxylase, which is the enzyme responsible for converting 5-hydroxytryptophan (5-HTP) to serotonin. Deficiency of vitamin B6 can impair this conversion and thus reduce serotonin production, which is linked to mood regulation and several neurological functions. A number of human and animal studies have shown that inadequate B6 status correlates with lowered serotonin levels and can contribute to mood disorders such as depression. Clinical trials have also examined B6 supplementation in conjunction with other treatments for depression and premenstrual syndrome (PMS), finding modest benefits, although the effects may be more pronounced in individuals with marginal or low B6 status. The scientific evidence is strong at the biochemical level, while clinical outcomes vary depending on study design and population. Overall, vitamin B6’s role in serotonin metabolism is well-established, and supplementation is justified in cases of deficiency or increased need.

More about Vitamin B6 (pridoxal 5-phosphate)
More about Serotonin

Other body systems supported by Vitamin B6 (pridoxal 5-phosphate)

Blood
Brain
Circulatory System
Digestive System
Glandular System
Heart
Immune System
Nerves
Serotonin

Products containing Vitamin B6 (pridoxal 5-phosphate)

We currently have no products on Caring Sunshine that contain this ingredient.