Evidence supporting the use of: Vitamin B6
For the body system: Serotonin
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Vitamin B6 (pyridoxine) plays a crucial role in the synthesis of neurotransmitters, including serotonin. Serotonin is produced from the amino acid tryptophan in a pathway that requires the enzyme aromatic L-amino acid decarboxylase, which uses vitamin B6 as a cofactor. Deficiency in vitamin B6 can limit serotonin production, potentially influencing mood and related neurological functions. Several studies have demonstrated that low B6 status is associated with depressive symptoms, and supplementation can normalize neurotransmitter synthesis in deficient individuals. However, the majority of clinical trials assessing B6 supplementation for mood disorders or serotonin-related conditions have yielded mixed results, often showing benefit mainly in those with clear B6 deficiency rather than in the general population. Systematic reviews suggest that while there is a mechanistic basis and some supportive data, evidence is not strong enough to recommend B6 supplementation for serotonin support in healthy individuals. Most reputable sources, such as the NIH Office of Dietary Supplements, acknowledge the importance of B6 for neurotransmitter synthesis but emphasize that supplementation beyond dietary needs does not consistently enhance serotonin function. In summary, there is scientific rationale and some clinical evidence for vitamin B6’s role in supporting the serotonin system, particularly in deficiency states, but its efficacy as a supplement for this purpose in the general population remains moderately supported.
Other ingredients that support Serotonin
5-Hydroxytryptophan (5-HTP)amino acids
California poppy
cowage seed
hops
inositol
l-tryptophan
lactium casein decapeptide
lavender
magnesium
omega-3 fatty acids
passionflower
phytocannabinoids
polygala root
pyridoxal-5-phosphate (P-5-P)
rhodiola
saffron
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sceletium
skullcap
vitamin B6
vitamin D
kanna
silk tree
St. John's Wort
5-Methoxytryptamine
Alpha lactalbumin
Baccosides
Bacopin
Brahmi
Bacopa
bacoside
Clary sage
Chocolate
Convolvulus prostratus
Convolvulus Pluricaulis
Celastrus
Dwarf Morning Glory
Products containing vitamin B6
Nature's Sunshine 5-HTP Power
Nature's Sunshine Adrenal Support
Nature's Sunshine AIVIA Clean Energy
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Plant Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine AIVIA Whey Protein
Nature's Sunshine Balanced B Complex (Vitamin B)
Nature's Sunshine Cardio Assurance
Nature's Sunshine Children's MultiVitamin & Mineral
Nature's Sunshine Glandular System
Nature's Sunshine Heavy Metal Detox
Nature's Sunshine Liquid - Methyl Vitamin B-12 Complete
Nature's Sunshine Love and Peas
Nature's Sunshine Mega-Chel
Nature's Sunshine MultiVitamin & Mineral (SynerPro)
Nature's Sunshine MultiVitamin & Mineral (Time Release)
Nature's Sunshine Natural Changes
Nature's Sunshine Nature's Prenatal
Nature's Sunshine Nature's Harvest
Nature's Sunshine Nervous System (30 Day Program)
Nature's Sunshine Nutri-Calm
Nature's Sunshine Nutri-Calm
Nature's Sunshine Power Beets Pouch
Nature's Sunshine Power Beets To-Go Packs
Nature's Sunshine Power Greens
Nature's Sunshine Power Greens To-Go
Nature's Sunshine Power Meal
Nature's Sunshine Power Meal
Nature's Sunshine Silver Shield BioGuard Hand & Body Cream
Nature's Sunshine Skeletal Strength
Nature's Sunshine Solstic Twenty-Four
Nature's Sunshine Solstic Energy
Nature's Sunshine Solstic Revive
Nature's Sunshine Structural System (30 Day Program)
Nature's Sunshine Super Supplemental
Nature's Sunshine Super Supplemental (Without Iron)
Nature's Sunshine Super Trio
Nature's Sunshine Thyroid Support
Nature's Sunshine B-Complex
Nature's Sunshine Vitamin B6
Nature's Sunshine VitaWave
