Evidence supporting the use of: Lithium
For the body system: Serotonin

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Lithium is primarily known as a mood stabilizer used in psychiatric medicine, especially for bipolar disorder. Its use is scientifically validated, particularly in the modulation of neurotransmitter systems, including serotonin. Research indicates that lithium can increase serotonin synthesis and release, enhance serotonin receptor sensitivity, and inhibit serotonin reuptake, thereby amplifying serotonergic neurotransmission in the brain. These effects are believed to contribute to its efficacy in reducing symptoms of depression and stabilizing mood in bipolar disorder.

Clinical studies have shown that lithium can augment the effects of antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), when treating refractory depression. This synergy further supports the role of lithium in supporting the serotonin system. Additionally, lithium’s neuroprotective and neurotrophic actions may involve serotonergic mechanisms, as increased serotonin activity is associated with improved neuroplasticity and neuronal health.

While lithium is not typically used as a first-line agent to "support the serotonin system" in the way that supplements or dietary interventions might be, its scientifically documented influence on serotonin pathways is a fundamental part of its therapeutic action in psychiatry. Thus, there is robust scientific evidence for lithium’s interaction with, and support of, the serotonin system, particularly in the context of mood disorders.

More about Lithium
More about Serotonin

Other body systems supported by Lithium

Brain
Dopamine
GABA
Nerves
Serotonin

Products containing Lithium

We currently have no products on Caring Sunshine that contain this ingredient.