Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactium is a patented bioactive decapeptide derived from casein, specifically αS1-casein hydrolysate, and is sometimes marketed for its potential calming and stress-relieving effects. There is limited scientific evidence suggesting that Lactium can modulate the body's stress response, primarily through its interaction with gamma-aminobutyric acid (GABA) receptors, rather than directly influencing the serotonin system. Some animal and human studies indicate that Lactium may help reduce stress-related symptoms, improve sleep quality, and lower cortisol levels. For example, several small randomized controlled trials have reported improvements in stress and sleep parameters among adults consuming Lactium supplements.

However, the connection between Lactium and the serotonin system is indirect at best. The primary mechanism appears to be through GABAergic activity, which can influence overall neurotransmitter balance, including serotonin, but there is no robust clinical evidence demonstrating a direct effect of Lactium on serotonin synthesis, release, or receptor activity. Thus, while there is some scientific support for Lactium's role in stress reduction, its use specifically to support the serotonin system is not strongly validated. The overall quality and quantity of evidence remain modest, and more research is needed to fully clarify its effects and mechanisms.

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