Evidence supporting the use of: Vitamin B12 (unspecified)
For the health condition: Senility

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B12 is scientifically recognized as an essential nutrient for neurological function and cognitive health. Deficiency in vitamin B12 can cause neurological symptoms that may mimic or contribute to cognitive decline and "senility" (an outdated term now generally replaced by "dementia" or "cognitive impairment"). Several observational and interventional studies have shown that older adults with low B12 levels are at increased risk for cognitive impairment and that B12 supplementation can improve cognitive symptoms in those who are deficient. However, evidence does not support B12 supplementation as a treatment for cognitive decline or dementia in individuals with normal B12 levels. Clinical guidelines recommend checking and correcting B12 deficiency in the evaluation of cognitive impairment in older adults. Randomized controlled trials in non-deficient populations have not demonstrated significant cognitive benefit from B12 supplementation. Thus, the use of vitamin B12 to treat or prevent "senility" is justified only in cases of deficiency, and not as a general cognitive enhancer. The evidence is moderate (rated 3 out of 5) because benefit is clear in deficiency states, but not in individuals with normal B12 levels.

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