Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Ketones, particularly in the context of ketone bodies produced by the liver during ketosis, have a well-established scientific basis for their use in supporting or treating seizures, especially in refractory epilepsy. The ketogenic diet, which is high in fats and very low in carbohydrates, induces a metabolic state where the body produces elevated levels of ketone bodies (such as beta-hydroxybutyrate and acetoacetate). Numerous clinical studies and reviews have demonstrated that this diet can significantly reduce seizure frequency in children and adults with drug-resistant epilepsy. The anti-seizure mechanism is not fully understood but is thought to involve alterations in brain energy metabolism, neurotransmitter balance, and neuronal excitability.

Importantly, the term "ketone (unspecified)" is broad; however, exogenous ketone supplements (like ketone esters) are being studied as adjunctive therapies to mimic the ketotic state without dietary restrictions. Early research suggests potential efficacy, but most robust evidence still centers on dietary-induced ketosis. The ketogenic diet has been in clinical use for epilepsy since the 1920s and remains a recommended option for certain patients by organizations such as the Epilepsy Foundation and American Epilepsy Society. Overall, there is substantial scientific validation for ketones' role in seizure management, though primarily via dietary methods rather than direct supplementation.

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