Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Azelaic acid has some scientific support for its use in seborrheic dermatitis (seborrhea), though the evidence is limited and not as robust as for other conditions like acne or rosacea. Azelaic acid is a naturally occurring dicarboxylic acid with anti-inflammatory, antimicrobial, and keratolytic properties. These attributes suggest a theoretical benefit for seborrheic dermatitis, a chronic inflammatory skin disorder characterized by erythema and scaling, often exacerbated by Malassezia yeast overgrowth.

Clinical studies specifically evaluating azelaic acid in seborrhea are sparse. A few small-scale studies and case reports have observed improvement in symptoms such as redness and scaling with topical azelaic acid, often at a 15-20% concentration. Its anti-inflammatory effect may help reduce the erythema and irritation, while the antimicrobial action could impact the yeast component. However, these studies are generally limited by small sample sizes, lack of blinding, or short duration.

Guidelines and dermatology texts occasionally mention azelaic acid as a secondary or adjunctive therapy in seborrheic dermatitis, especially for patients who are intolerant to first-line treatments like antifungals or corticosteroids. Despite some promising findings, azelaic acid is not considered a first-line therapy, and more rigorous, large-scale randomized controlled trials are needed to solidify its role.

In summary, there is modest scientific evidence supporting azelaic acid for seborrheic dermatitis, but it is not the standard of care. Its use may be justified in certain situations, but more research is warranted.

More about Azelaic acid
More about Seborrhea

Other ingredients used for Seborrhea

Other health conditions supported by Azelaic acid

Products containing Azelaic acid