Silk protein, particularly in the form of silk fibroin, has been investigated in biomedical research for its potential to support wound healing and improve scar outcomes. Scientific studies indicate that silk fibroin possesses excellent biocompatibility, minimal immunogenicity, and beneficial mechanical properties, making it suitable for use in wound dressings and tissue engineering. Research has demonstrated that silk-based biomaterials can promote cell adhesion, proliferation, and migration—key processes in tissue repair.

In vitro and animal studies have shown that silk fibroin scaffolds can enhance the healing of skin wounds, possibly by modulating the inflammatory response and supporting organized collagen deposition, which may reduce excessive scar formation. Some clinical studies and case reports have utilized silk-derived dressings for burn or surgery-related wounds with promising results regarding healing rates and cosmetic outcomes. However, large-scale, high-quality randomized controlled trials in humans specifically examining the reduction or treatment of established scar tissue are limited.

Overall, silk protein's use in supporting scars and scar tissue is grounded in scientific exploration, though the evidence base is still emerging and primarily preclinical or early clinical. More robust clinical trials are needed to definitively establish efficacy for scar treatment.