Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Proteolytic enzymes, such as bromelain, trypsin, chymotrypsin, and serratiopeptidase, have been investigated for their potential role in supporting the healing of scars and scar tissue. The scientific rationale is that these enzymes can help break down excess fibrin and other proteins involved in scar formation, potentially reducing inflammation and modulating tissue repair. Some clinical studies, particularly with serratiopeptidase and bromelain, have shown a reduction in post-surgical swelling, bruising, and pain, which are associated with tissue repair and could indirectly impact scar formation. For instance, a few small randomized controlled trials have suggested that oral administration of these enzymes may lead to faster resolution of edema and improved wound healing. However, direct evidence regarding the reduction or prevention of established scars and scar tissue is limited and inconsistent. Most available studies are small, sometimes lacking in rigorous methodology, and often focus on related outcomes (such as swelling or pain) rather than scar visibility or pliability. Major clinical guidelines do not currently recommend proteolytic enzymes specifically for scar treatment, and more robust studies are needed. Thus, while there is some scientific exploration and limited evidence suggesting a possible benefit, it remains preliminary.

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