Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Proline is an amino acid that plays a crucial role in the synthesis of collagen, which is a major structural protein in skin and connective tissue. Collagen is essential for wound healing and the formation of new tissue, and proline is a key substrate in collagen biosynthesis. Scientifically, there is a rationale for proline’s involvement in tissue repair and, by extension, scar formation. However, while dietary or supplemental proline is important for overall collagen health, direct clinical evidence supporting the use of supplemental proline specifically for improving scars or reducing scar tissue in humans is limited.

Most of the available evidence is based on the biochemistry of collagen formation and animal studies, rather than well-controlled human clinical trials. Some studies suggest that proline, along with other amino acids like glycine and hydroxyproline, may enhance wound healing, but these findings are preliminary. In practice, proline is sometimes included in oral or topical products marketed for skin health or scar improvement, but robust, high-quality evidence to definitively support its effectiveness for treating scars is lacking. Therefore, while the scientific rationale exists, the direct evidence for scar treatment is weak, warranting a low-to-moderate rating.

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