Evidence supporting the use of: Fibroblast growth factors
For the health condition: Scars / Scar Tissue

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Fibroblast growth factors (FGFs) are a family of signaling proteins involved in processes such as cell proliferation, differentiation, and tissue repair. The scientific rationale for using FGFs to support or treat scars and scar tissue is based on their role in wound healing. FGFs, particularly basic FGF (bFGF or FGF2), have been shown in both in vitro and in vivo studies to promote the proliferation and migration of fibroblasts, which are essential for tissue regeneration and repair. Several animal studies and limited clinical trials have suggested that topical or injectable FGFs can improve wound healing rates, reduce scar formation, and enhance the quality of the regenerated tissue, making scars less pronounced or more similar to normal skin. For example, randomized controlled trials in humans have demonstrated that bFGF application after surgical incisions or burns can result in better aesthetic outcomes and lower hypertrophic scarring compared to controls. However, most of the evidence is from small or preliminary studies, and large-scale, long-term clinical trials are still lacking. Thus, while the mechanism is scientifically plausible and early results are promising, the overall quality and quantity of evidence supporting widespread FGF use for scar management is moderate but not yet definitive.

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Products containing fibroblast growth factors

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